Effects of GPI-1046 at 10 mg/kg (GPI-10, n=6), GPI-1046 at 20 mg/kg (GPI-20, n=6), vehicle (ethanol naïve) (n=6), water naive (water) (n=6) groups on GLT1 expression in NAc-core. (A) Each panel presents immunoblots for β-tubulin, which was used as a control loading protein, and GLT1. (B) Quantitative analysis revealed a significant increase in the ratio of GLT1/β-tubulin in GPI-10 and GPI-20-treated groups as compared to vehicle (ethanol naïve). Significant increases in GLT1 expression was revealed in GPI-20 as compared to GPI-10 and water naive (water) groups. Alternatively, statistical analysis revealed significant down-regulation of GLT1 expression in vehicle group as compared to naive group. Error bars indicate SEM. (*p<0.05; **p<0.01; ***p<0.001.)