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. 2012 Apr 25;32(17):5973–5983. doi: 10.1523/JNEUROSCI.3873-11.2012

Figure 5.

Figure 5.

Intrathecal EPO elicits a long-lasting pMF. A, Representative compressed phrenic neurograms showing either pMF after EPO injection (filled arrow) or no facilitation after vehicle injection (open arrow). B, Preliminary dose–response curve for EPO; the dose subsequently used confers pMF without effects on hypoglossal (XII) activity. *p < 0.001, significantly different from XII motor facilitation at same dose. C, The amplitude of integrated phrenic bursts increases from baseline after 10 μl (20 IU) EPO injections (n = 8; filled circles) and is significantly different from vehicle controls at the same time point (10 μl; n = 6; open circles). All values are change in phrenic burst amplitude as percentage baseline. Mean values ± 1 SEM. †p < 0.05, significantly different from baseline. *p < 0.05, significantly different from vehicle at the same time.