Figure 7.

Effects of drug administration on nerve burst frequency. A, Intrathecal administration of 10 IU EPO (filled circles) elicits a small facilitation in nerve burst frequency at 60 min after injection versus baseline and vehicle controls (open circles; n = 4; *p < 0.027). B, The only dose of EPO that elicited frequency facilitation was 10 IU (*p < 0.027). Higher (20 and 30 IU) and lower (4 IU) doses did not elicit frequency facilitation (all p > 0.05). C, D, No other treatments, including U0126, U0126 + EPO, LY294002, and LY294002 + EPO, elicited frequency facilitation versus baseline (all p > 0.05). All values are expressed as change in nerve burst frequency (percentage baseline). Mean values ± 1 SEM.