Table 1.
Body temperature (Tb), blood gases, pH, mean arterial pressure (MAP), and standard base excess (SBE) in each treatment group
| Group | Tb (°C) | PaO2 (mmHg) | PaCO2 (mmHg) | pH | MAP (mmHg) | SBE |
|---|---|---|---|---|---|---|
| Baseline | ||||||
| aCSF + 0.1% BSA | 37.2 ± 0.2 | 335.5 ± 13.2 | 46.0 ± 0.9 | 7.335 ± 0.005 | 121.3 ± 5.9 | −1.15 ± 0.41 |
| 20 IU EPO | 37.1 ± 0.1 | 305.9 ± 13.7 | 45.8 ± 1.0 | 7.347 ± 0.009 | 119.2 ± 4.2 | −0.46 ± 0.70 |
| U0126 + EPO | 36.9 ± 0.2 | 319.6 ± 17.8 | 46.4 ± 1.1 | 7.343 ± 0.008 | 119.1 ± 2.6 | −0.50 ± 0.42 |
| U0126 alone | 37.4 ± 0.1 | 306.2 ± 10.5 | 46.4 ± 0.9 | 7.344 ± 0.011 | 117.3 ± 7.3 | −0.52 ± 0.69 |
| LY294002 + EPO | 37.1 ± 0.2 | 310.0 ± 14.1 | 47.5 ± 0.4 | 7.335 ± 0.008 | 116.8 ± 4.6 | −0.46 ± 0.57 |
| LY294002 alone | 37.7 ± 0.1 | 292.3 ± 13.3 | 46.1 ± 0.8 | 7.333 ± 0.008 | 110.7 ± 7.1 | −1.36 ± 0.61 |
| 15 min | ||||||
| aCSF + 0.1% BSA | 37.6 ± 0.1 | 318.5 ± 7.2 | 46.3 ± 0.9 | 7.335 ± 0.005 | 109.3 ± 3.2 | −1.13 ± 0.55 |
| 20 IU EPO | 37.2 ± 0.1 | 297.4 ± 14.8 | 45.5 ± 1.4 | 7.344 ± 0.010 | 116.4 ± 5.8 | −0.61 ± 0.85 |
| U0126 + EPO | 37.2 ± 0.1 | 319.3 ± 18.0 | 47.1 ± 0.8 | 7.334 ± 0.016 | 118.3 ± 6.6 | −0.73 ± 0.81 |
| U0126 alone | 37.2 ± 0.2 | 289.3 ± 7.2 | 47.2 ± 0.7 | 7.341 ± 0.019 | 112.0 ± 15.8 | −0.10 ± 1.05 |
| LY294002 + EPO | 37.2 ± 0.2 | 315.5 ± 4.9 | 48.0 ± 0.3 | 7.338 ± 0.009 | 108.6 ± 2.0 | 0.03 ± 0.58 |
| LY294002 alone | 37.4 ± 0.1 | 300.0 ± 8.6 | 46.0 ± 0.7 | 7.336 ± 0.008 | 108.4 ± 6.1 | −1.17 ± 0.65 |
| 30 min | ||||||
| aCSF + 0.1% BSA | 37.4 ± 0.1 | 330.3 ± 9.0 | 46.0 ± 0.8 | 7.336 ± 0.005 | 115.0 ± 7.8 | −1.10 ± 0.49 |
| 20 IU EPO | 37.1 ± 0.1 | 300.9 ± 13.1 | 46.9 ± 1.0 | 7.339 ± 0.010 | 112.5 ± 6.6 | −0.48 ± 0.79 |
| U0126 + EPO | 37.1 ± 0.1 | 307.2 ± 15.1 | 47.0 ± 1.1 | 7.343 ± 0.013 | 112.8 ± 5.6 | −0.18 ± 0.63 |
| U0126 alone | 37.4 ± 0.1 | 288.2 ± 9.4 | 46.3 ± 0.8 | 7.341 ± 0.014 | 112.6 ± 11.9 | −0.67 ± 0.76 |
| LY294002 + EPO | 37.3 ± 0.1 | 304.0 ± 8.1 | 48.0 ± 0.7 | 7.337 ± 0.008 | 107.6 ± 2.5 | −0.10 ± 0.58 |
| LY294002 alone | 37.3 ± 0.1 | 294.4 ± 9.6 | 46.3 ± 0.8 | 7.335 ± 0.009 | 102.2 ± 5.5 | −1.04 ± 0.64 |
| 60 min | ||||||
| aCSF + 0.1% BSA | 37.0 ± 0.2 | 324.8 ± 8.5 | 45.9 ± 1.0 | 7.340 ± 0.010 | 111.3 ± 7.5 | −0.92 ± 0.74 |
| 20 IU EPO | 37.2 ± 0.1 | 305.5 ± 12.3 | 45.8 ± 1.0 | 7.339 ± 0.009 | 109.2 ± 6.6 | −1.01 ± 0.71 |
| U0126 + EPO | 37.2 ± 0.4 | 331.5 ± 1.8 | 46.8 ± 1.0 | 7.360 ± 0.001 | 113.4 ± 7.5 | 0.95 ± 0.39 |
| U0126 alone | 37.2 ± 0.1 | 300.7 ± 6.8 | 45.9 ± 0.7 | 7.343 ± 0.017 | 108.7 ± 10.9 | −0.75 ± 0.91 |
| LY294002 + EPO | 37.2 ± 0.2 | 302.6 ± 6.3 | 47.4 ± 0.4 | 7.337 ± 0.007 | 104.1 ± 2.5 | −0.34 ± 0.54 |
| LY294002 alone | 37.6 ± 0.1 | 299.6 ± 10.9 | 45.7 ± 0.6 | 7.343 ± 0.010 | 97.4 ± 5.9 | −0.83 ± 0.82 |
| 90 min | ||||||
| aCSF + 0.1% BSA | 37.1 ± 0.2 | 321.8 ± 8.0 | 45.7 ± 1.0 | 7.348 ± 0.012* | 108.2 ± 6.8* | −0.52 ± 0.79 |
| 20 IU EPO | 37.3 ± 0.2 | 305.9 ± 11.4 | 46.2 ± 1.0 | 7.337 ± 0.011* | 106.4 ± 6.1* | −0.97 ± 0.68 |
| U0126 + EPO | 37.0 ± 0.1 | 320.2 ± 11.9 | 46.6 ± 1.4 | 7.355 ± 0.012* | 102.6 ± 6.4* | −0.10 ± 1.03 |
| U0126 alone | 37.2 ± 0.2 | 300.5 ± 9.1 | 46.5 ± 1.3 | 7.347 ± 0.018 | 104.1 ± 10.2* | −0.17 ± 0.78 |
| LY294002 + EPO | 37.2 ± 0.2 | 299.4 ± 3.9 | 47.8 ± 0.6 | 7.338 ± 0.007 | 100.6 ± 2.1* | −0.16 ± 0.31 |
| LY294002 alone | 37.1 ± 0.2 | 301.7 ± 8.7 | 45.9 ± 0.8 | 7.353 ± 0.014* | 101.4 ± 6.4* | 0.02 ± 1.03 |
All values expressed as mean ± SEM.
* indicates significantly different from respective baseline measurement.