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. Author manuscript; available in PMC: 2012 Nov 26.
Published in final edited form as: J Hepatol. 2012 Mar 13;57(2):453–454. doi: 10.1016/j.jhep.2012.03.004

Fig. 1. Summary of the role of sex hormones in HCC.

Fig. 1

Different data indicate a pro-tumorigenic role of androgens in both the cirrhotic and normal liver. However, evidence from experimental models of chemically-induced HCC suggests that estrogens may be protective in this setting by interfering with IL6 production and FOXA DNA binding sites.