Figure 5.

Gfa2–VIVIT improves cognitive performance in Tg mice. Percentage avoidances (mean ± SEM) by WT (A) and Tg (B) mice exhibited on three training days (Day 1, Day 2, Day 3) in a one-way active avoidance task. Gfa2–VIVIT had little effect on avoidance behavior in WT mice (A) but tended to improve performance in the Tg group by the end of training (B). On day 4 of the task, mice completed a single probe trial (C) in the absence of footshock and received rankings (mean ± SEM ranking) according to their escape times (lower ranks correspond to quicker escape latencies). Mean rankings for the WTs and Tg VIVIT groups were very similar on the probe trial and significantly lower than the Tg Ct group (* p > 0.05 Tg Ct vs all other groups).