Table 2.

Individual Predicted Median NVP Pharmacokinetic Parameters from the Final Model (n=359)

NVP PK	Week 2 (IQR)*	Week 4 (IQR)*	p-value**
CL/F(L/hr)	1.6 (1.4, 1.8)	2.0 (1.8, 2.3)	<0.001
AUC24 hr (mcg*hr/mL)	124.2 (109.0, 144.7)	200.9 (174.4, 227.5)	<0.001
Cmin (mcg/mL)	4.0 (3.4, 4.8)	7.2 (6.1, 8.3)	<0.001
Cmax (mcg/mL)	6.3 (5.7, 7.2)	9.3 (8.2, 10.4)	<0.001

^*IQR= Interquartile range

^**Wilcoxon signed rank test

CL/F = oral clearance

AUC₂₄ = steady state 24 hr area under the curve

C_min = minimum plasma concentrations

C_max= maxiumum plasma concentrations