. 2012 Oct 8;55(22):9868–9874. doi: 10.1021/jm301096s

Table 2. Antagonist Activity (K_e, nM) for test Compounds at Opioid Receptors Determined in Mouse Vas Deferens.

	K_e, nM^a
ligand	MOR	DOR	KOR
3a	0.83 ± 0.04	6.84 ± 2.00	ND
6	0.20 ± 0.02	3.89 ± 0.99	1.05 ± 0.13
4a	0.72 ± 0.11	6.20 ± 3.28	1.89 ± 0.17
5a	0.021 ± 0.002	1.25 ± 0.38	0.047 ± 0.005
3b^b	0.02 ± 0.007	0.25 ± 0.06	0.19 ± 0.06
4b^c	0.56 ± 0.15	0.94 ± 0.14	1.24 ± 0.12
5b^c	0.008 ± 0.0006	0.044 ± 0.005	0.052 ± 0.003

The selective agonists used were DAMGO (MOR), DPDPE (DOR), U69593 (KOR). ND = not determined. Buprenorphine is an agonist in the mouse vas deferens with an EC₅₀ of 21 nM (ref (14)).

Data from ref (21).

Data from ref (6).

Table 2. Antagonist Activity (Ke, nM) for test Compounds at Opioid Receptors Determined in Mouse Vas Deferens.

Table 2. Antagonist Activity (K_e, nM) for test Compounds at Opioid Receptors Determined in Mouse Vas Deferens.