Abstract
The antitumor activity of a mixture of synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and trehalose-6,6'-dimycolate (TDM) (MDP+TDM) in emulsified form was studied in guinea pigs, each with a syngeneic dermal tumor and microscopically detectable metastases in regional lymph nodes. A single intralesional administration of an ultrasonically prepared emulsion containing MDP+TDM in squalane or in mineral oil caused tumor regression and elimination of lymph node metastases. Similar emulsions of MDP+TDM made with squalene or hexadecane were immunotherapeutically inactive.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ellouz F., Adam A., Ciorbaru R., Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317–1325. doi: 10.1016/0006-291x(74)90458-6. [DOI] [PubMed] [Google Scholar]
- Kotani S., Watanabe Y., Kinoshita F., Shimono T., Morisaki I. Immunoadjuvant activities of synthetic N-acetyl-muramyl-peptides or -amino acids. Biken J. 1975 Jun;18(2):105–111. [PubMed] [Google Scholar]
- McLaughlin C. A., Schwartzman S. M., Horner B. L., Jones G. H., Moffatt J. G., Nestor J. J., Jr, Tegg D. Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate. Science. 1980 Apr 25;208(4442):415–416. doi: 10.1126/science.7189295. [DOI] [PubMed] [Google Scholar]
- Rapp H. J. A guinea pig model for tumor immunology. A summary. Isr J Med Sci. 1973 Mar;9(3):366–374. [PubMed] [Google Scholar]
- Ribi E. E., Cantrell J. L., Von Eschen K. B., Schwartzman S. M. Enhancement of endotoxic shock by N-acetylmuramyl-L-alanyl-(L-seryl)-D-isoglutamine (muramyl dipeptide). Cancer Res. 1979 Nov;39(11):4756–4759. [PubMed] [Google Scholar]
- Yarkoni E., Meltzer M. S., Rapp H. J. Tumor regression after intralesional injection of emulsified trehalose-6,6'-dimycolate (cord factor): efficacy increases with oil concentration. Int J Cancer. 1977 Jun 15;19(6):818–821. doi: 10.1002/ijc.2910190612. [DOI] [PubMed] [Google Scholar]
- Yarkoni E., Rapp H. J. Influence of type of oil and surfactant concentration on the efficacy of emulsified Mycobacterium bovis BCG cell walls to induce tumor regression in guinea pigs. Infect Immun. 1980 Jun;28(3):881–886. doi: 10.1128/iai.28.3.881-886.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]