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. Author manuscript; available in PMC: 2012 Nov 26.
Published in final edited form as: Psychiatr Clin North Am. 2012 Jun;35(2):495–519. doi: 10.1016/j.psc.2012.03.010

Fig. 8.

Fig. 8

The serotonin-transporter-linked polymorphic region. The human serotonin transporter promoter has a common VNTR termed HTTLPR. The major alleles within this VNTR, namelyL (long) and S (short), differ in number of copies of a 20-bpto23-bp imperfect repeat. The L allele, which leads to increased transcription efficiency, has 16 copies of the repeat and the S allele has 14 copies. Further, a relatively common, functional A > G SNP within the L allele leads to an LG allele functionally equivalent to the S allele. (Data from Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274(5292):1527-31; and Hu XZ, Lipsky RH, Zhu G, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive compulsive disorder. Am J Hum Genet 2006;78(5):815–26.)