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. 2012 Jun 22;61(12):2357–2366. doi: 10.1007/s00262-012-1297-2

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© The Author(s) 2012

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Modulation of dysregulated Treg and NK cells in malignant patients. After type 1 treatment, the overinduced Treg (a, CD4⁺CD25^+high) in a representative malignant patient could be modulated to 0.4 % (b), and the NK cells remained normal (c, d). After type 2 treatment, the downregulated NK (e, CD3⁻CD56⁺) in a representative malignant patient could be elevated to 21.9 % (f), and the Treg remained normal (g, h)