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. 2012 Jun 22;61(12):2357–2366. doi: 10.1007/s00262-012-1297-2

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© The Author(s) 2012

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Correction of fluctuated Treg and NK cells by multiple types of treatment. After type 1 treatment, the NK cells (CD3⁻CD56⁺, lower row) in a malignant patient with overinduced Treg (CD4⁺CD25^+high, upper row) (a) were downregulated to 7.1 % (b). Upon subsequent two courses of type 3 treatment, the NK population became >10 % (c). After another type 1 treatment, the Treg was <3 % with >10 % NK population (d)