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. 2012 Nov 7;32(45):15769–15778. doi: 10.1523/JNEUROSCI.2180-12.2012

Figure 4.

Figure 4.

SCH202676, an inhibitor of G-protein-coupled receptors inhibited airflow-sensitive and odor-stimulated responses. A, SCH202676 at 100 μm completely inhibited the airflow-sensitive response generated by an airflow of 2.4 L/min. Top, Representative EOG traces of the airflow-sensitive response. Bottom, Bar graph of data; n = 13, **p < 0.01. B, SCH202676 at 100 μm partially inhibited the EOG odor response. The EOG odor response was evoked by an air puff (2.4 L/min; puff duration, 200 ms) containing an odorant mix. Top, Representative EOG traces of odor response. Bottom, Bar graph of data; n = 7; **p < 0.01. Neither inhibition (airflow response or odor response) by SCH202676 was reversible. C, SCH202676 abolished the oscillation of the EOG response at 2 and 3 Hz air puff (pure N2)-induced EOG field potentials. Left, Control. Right, Addition of SCH202676 (100 μm). Bottom inset, Enlarged traces showing that oscillations of EOG response was abolished in the presence of SCH202676. Flow rate: 0.5 L/min; air-puff duration: 200 ms; n = 7.