Figure 7.

Air puffs failed to stimulate an airflow-sensitive EOG response in AC3^−/− mice. A, Representative EOG traces stimulated by single air puffs (2.4 L/min for 200 ms) to the MOE of AC3^+/+ (n = 12) and from AC3^−/− mice (n = 8). B, AC3^−/− mice also failed to display oscillation as well as downward EOG response upon 1 and 2 Hz air-puff stimulations. Flow rate: 0.5 L/min; puff duration: 200 ms. C, EOG responses of AC3^+/+ and AC3^−/− MOE (exemplar traces are from two wild-type and two knock-out mice) to air puffs of varying flow rates. D, Bar graph for flow rate-dependent airflow-sensitive responses for AC3^+/+ (n = 9) and AC3^−/− mice (n = 9).