Figure 1 .

Study schema for serial monitoring of arthritic inflammation & disease. Six rats were injected intradermally with Type II collagen (CII) in incomplete Freund’s adjuvant on days 0 and 7. Animals were randomized into study cohorts (3 per group) on day 13, and all injected with PFC contrast agent. Two days later animals were imaged by ¹H ¹⁹F MRI, and placed on daily vehicle or prednisolone for the duration of the study. MRI was repeated at weekly intervals 48 hours after contrast agent administration. Clinical measurements of ankle swelling and animal weight were conducted from day 15 (after the initial collagen immunization) to study end, every 3 to 4 days.