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. 2012 Nov 26;7(11):e48015. doi: 10.1371/journal.pone.0048015

Figure 2. Multiple sequence alignment of bcPadR1, bcPadR2, and other members of the PadR-s2 subfamily.

Figure 2

Only sequences for which structures are available in the PDB are shown in the alignment. The PadR-s2 proteins with unpublished structures are addressed by their PDB entry names: 1XMA, a putative transcriptional regulator from Clostridium thermocellum; 3HHH, a putative transcriptional regulator from Enterococcus faecalis V583; 3L7W, uncharacterized protein SMU.1704 from Streptococcus mutans UA159; 3RI2, a putative transcriptional regulator from Eggerthella lenta DSM 2243. Residues that participate in dimerization (for bcPadR1, bcPadR2, and LmrR) and/or have a role in drug binding (only for LmrR) are indicated by small spheres below the sequences. The consensus sequence is derived from a multiple sequence alignment of 2156 PadR-s2 proteins using as criteria that the conserved residue(s) should be present in at least 50% of the sequences.