Skip to main content
. 2012 Nov 26;7(11):e48232. doi: 10.1371/journal.pone.0048232

Figure 13. CUSP-MFM enables the estimation of diffusion tensor parameters which do not vary with the partial volume effect.

Figure 13

We computed the FA along a same tract (Fig.a) for various artificial rotations of the diffusion-weighted images. For each streamline point, the most aligned anisotropic tensor with the streamline orientation was selected and its FA assessed. Fig.b shows the variance of the FA along the tract across the rotations, when using the CUSP or the HARDI acquisition and the MFM estimator without regularization and with the same parameters. HARDI has dramatically increased variance, as it conflates tensor size with partial voluming. CUSP does not. Fig.c shows the FA variance when adding the regularization to the estimation with both CUSP and HARDI. Fig.d shows the corresponding value of the FA along the tract. It shows that CUSP-MFM enables estimation of diffusion tensor parameters which do not vary with the partial volume fractions nor the regularization.