Table 3. Gallbladder dynamics in patients with Crohn's colitis and disease controls during the first 6 hours after CDCA ingestion and after 8 days of CDCA ingestion.
| Crohn's patients | Disease controls | ||
| N = 9 | N = 12 | p-value | |
| During the first 6 hrs after CDCA ingestion | |||
| V0 (mL) | 20.7 (7.02) | 24.6 (8.48) | 0.29 |
| Vmin (mL) | 17.5 (7.17) | 20.9 (7.11) | 0.48 |
| Vmin (%) | 86 (18) | 89 (20) | 0.59 |
| ΔVmin (mL) | −3.1 (3.7) | −3.7 (6.4) | 0.88 |
| ΔVmin (%) | −15 (18) | −12 (20) | 0.59 |
| Time Vmin (hours) | 0.56 (0.53) | 0.75 (1.42) | 0.69 |
| Vmax (mL) | 36.3 (11.1) | 41.4 (15.1) | 0.36 |
| Vmax (%) | 190 (69) | 178 (51) | 0.83 |
| ΔVmax (mL) | 15.7 (10.1) | 16.9 (12.9) | 1.00 |
| ΔVmax (%) | 90 (68) | 78 (51) | 0.83 |
| Time Vmax (hours) | 5.11 (1.05) | 3.67 (1.83) | 0.04 |
| AUC (mL*360 min) | 2766 (2407) | 3053 (3907) | 0.89 |
| AUC (percent*360 min) | 16204 (15101) | 15199 (15489) | 0.94 |
| After 8 days of CDCA ingestion | |||
| V_t8 (mL) | 39.5 (18.0) | 49.6 (20.7) | 0.23 |
| V_t8 (%) | 199 (79) | 208 (94) | 1.00 |
| ΔV_t8 (mL) | 18.8 (14.3) | 25.0 (17.4) | 0.32 |
| ΔV_t8 (%) | 99 (79) | 108 (94) | 1.00 |
Values are in means ± SD; CDCA, chenodeoxycholic acid; V0, baseline fasting gallbladder volume (mean of 3 measurements);Vmin (mL), minimal gallbladder volume; Vmin (%), minimal gallbladder volume as percentage of V0; ΔVmin (mL), difference between Vmin and V0; ΔVmin (%), percentual difference between Vmin and V0; Time Vmin (hours), time to minimal gallbladder volume from t0; Vmax (mL), maximal gallbladder volume; Vmax (%), maximal gallbladder volume as percentage of V0; ΔVmax (mL), difference between Vmax and V0; ΔVmax (%), percentual difference between Vmax and V0; Time Vmax (hours), time to maximal gallbladder volume from t0; AUC (mL*360 min), area under the curve of change of gallbladder volume during 360 minutes; AUC (percent*360 min), area under the curve of percentual change of gallbladder volume during 360 minutes; V_t8 (mL), gallbladder volume after 8 days of CDCA ingestion; V_t8 (%), V_t8 as percentage of V0; ΔV_t8 (mL), difference between V_t8 and V0; ΔV_t8 (%), percentage difference between V_t8 and V0.