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. 2012 Nov 27;3:454. doi: 10.3389/fphys.2012.00454

Table 1.

Lipid classes and indexes in lipid rafts from isolated from frontal cortex of WT and APP/PS1 aged 6 and 14 months.

WT 6 months APP 6 months WT 14 months APP 14 months
Sphingomyelin (SM)1 3.17 ± 0.15c 4.71 ± 0.34***c 6.05 ± 0.81 7.25 ± 0.47
Phosphatidylcholine (PC)1 11.62 ± 1.37a 12.27 ± 0.18b 15.58 ± 0.45 15.85 ± 0.78
Cholesterol (CHO)1 31.88 ± 4.75 29.40 ± 1.01c 25.94 ± 0.47 22.97 ± 0.95**
SM/PC 0.30 ± 0.05 0.48 ± 0.03** 0.40 ± 0.06 0.46 ± 0.05
SM/CHO 0.11 ± 0.01c 0.16 ± 0.02c 0.24 ± 0.03 0.32 ± 0.02*
Saturated2 58.45 ± 0.92c 59.95 ± 0.14c 68.15 ± 1.46 71.89 ± 1.01*
Unsaturated2 38.25 ± 2.20b 31.05 ± 2.48* 31.03 ± 1.32 27.45 ± 1.04*
Monoenes2 20.65 ± 1.41 17.81 ± 1.78 18.46 ± 0.65 18.46 ± 1.05
LCPUFA2 16.72 ± 2.04a 11.90 ± 0.63b 12.27 ± 0.90 8.66 ± 0.65***
Total n-92 13.36 ± 1.22a 10.02 ± 1.91 10.73 ± 0.68 9.80 ± 0.82
Total n-62 8.93 ± 0.57c 7.71 ± 0.35c 6.45 ± 0.44 4.92 ± 0.35**
Total n-32 8.49 ± 1.38a 5.47 ± 0.36b 5.92 ± 0.53 3.78 ± 0.32***
saturated/unsaturated 1.56 ± 0.13c 1.97 ± 0.16*b 2.23 ± 0.14 2.64 ± 0.15*
saturated/n-3 7.75 ± 1.38b 11.11 ± 0.76c 12.07 ± 1.28 19.50 ± 1.46***
saturated/n-6 6.67 ± 0.50c 7.80 ± 0.37c 10.87 ± 0.92 14.90 ± 1.05**
saturated/n-9 4.57 ± 0.54b 6.72 ± 1.29 6.53 ± 0.58 7.63 ± 0.90
saturated/CHO 1.99 ± 0.27a 2.04 ± 0.07c 2.63 ± 0.07 3.15 ± 0.11***
SM/unsaturated 0.08 ± 0.01c 0.15 ± 0.00***c 0.20 ± 0.03 0.26 ± 0.02
SM/n-3 LCPUFA 0.41 ± 0.06c 0.86 ± 0.00***c 1.08 ± 0.16 1.95 ± 0.14***
CHO/unsaturated 0.83 ± 0.10 0.96 ± 0.11 0.84 ± 0.04 0.85 ± 0.07
CHO/LCPUFA 1.90 ± 0.13 2.49 ± 0.22** 2.17 ± 0.17 2.69 ± 0.15*
Phospholipids/Cholesterol 1.81 ± 0.35 1.78 ± 0.09c 2.22 ± 0.07 2.61 ± 0.11**
Unsaturation index 105.99 ± 10.72b 78.91 ± 5.18b 79.32 ± 5.04 60.40 ± 3.18**

Data are expressed mean ± SEM for 4–5 animals in each group of genotype and age.

1

Weight percent respect to total lipids from lipid raft,

2

weight percent respect to total fatty acids from lipid raft.

*

,

**

,

***

Indicate statistical differences with p = 0.1, p = 0.05 and p = 0.01 between genotypes of same age.

a

,

b

,

c

Indicate statistical differences with p = 0.1, p = 0.05 and p = 0.01 between ages within each genotype.