Table 3.
Changes in left ventricular parameters with cardiac resynchronization therapy on by kidney function groupa
| Baseline | 12 months | Paired difference |
P-value |
||
|---|---|---|---|---|---|
| P (between baseline and 12 months) | P (between the paired differences) | ||||
| LVEF (%) | |||||
| No CKD | 27.1 (0.4) | 32.0 (0.6) | –5.0 (0.6) | <0.001 | 0.048 |
| CKD | 27.6 (0.7) | 30.3 (0.9) | –2.7 (0.9) | 0.002 | |
| LVESV (mL) | |||||
| No CKD | 197.7 (5.1) | 159.8 (5.5) | –37.8 (4.0) | <0.001 | 0.019 |
| CKD | 194.0 (6.9) | 172.7 (7.6) | –21.3 (5.1) | <0.001 | |
| LVEDV (mL) | |||||
| No CKD | 267.2 (6.0) | 228.3 (6.3) | –38.9 (4.4) | <0.001 | 0.045 |
| CKD | 265.8 (8.4) | 242.9 (9.0) | –22.9 (6.2) | <0.001 | |
| LVESD (cm) | |||||
| No CKD | 5.7 (0.1) | 5.3 (0.1) | –0.4 (0.1) | <0.001 | 0.052 |
| CKD | 5.6 (0.1) | 5.5 (0.1) | –0.1 (0.1) | 0.46 | |
| LVEDD (cm) | |||||
| No CKD | 6.8 (0.1) | 6.5 (0.1) | –0.3 (0.1) | <0.001 | 0.10 |
| CKD | 6.8 (0.1) | 6.7 (0.1) | –0.1 (0.1) | 0.23 | |
| LV mass (g) | |||||
| No CKD | 270.4 (6.7) | 249.5 (6.2) | –20.9 (4.6) | <0.001 | 0.035 |
| CKD | 274.3 (11.8) | 273.3 (10.7) | –1.0 (8.4) | 0.91 | |
| Mitral regurgitation (%) | |||||
| No CKD | 14.5 (0.9) | 12.9 (0.9) | –1.6 (0.9) | 0.073 | 0.026 |
| CKD | 15.4 (1.3) | 17.4 (1.7) | 2.0 (1.4) | 0.16 | |
| LV cavity shape–diastole | |||||
| No CKD | 0.53 (0.008) | 0.48 (0.008) | –0.057 (0.008) | <0.001 | 0.0059 |
| CKD | 0.52 (0.01) | 0.50 (0.01) | –0.016 (0.011) | 0.14 | |
| IVMD (ms) | |||||
| No CKD | 37.5 (3.1) | 24.7 (2.7) | –12.8 (3.2) | <0.001 | 0.66 |
| CKD | 24.1 (4.6) | 14.0 (4.4) | –10.1 (5.2) | 0.057 | |
| MPI | |||||
| No CKD | 971 (9.1) | 961 (9.5) | –10.6 (9.3) | 0.26 | 0.23 |
| CKD | 953 (16) | 964 (18) | 11 (16) | 0.50 | |
CKD, chronic kidney disease; IVMD, interventricular mechanical delay; LV cavity shape–diastole, left ventricular cavity shape at end-diastole; LVEDD, left ventricular end-diastolic diameter; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; LVESV, left ventricular end-systolic volume; LV mass, left ventricular mass; MPI, myocardial performance index.
aValues represent the mean (standard error).