Table 4.
Changes in left ventricular parameters with cardiac resynchronization therapy off by kidney function groupa
| Baseline | 12 months | Paired difference |
P-value |
||
|---|---|---|---|---|---|
| P (between baseline and 12 months) | P (between the paired differences) | ||||
| LVEF (%) | |||||
| No CKD | 25.7 (0.7) | 26.3 (0.7) | –0.7 (0.6) | 0.3 | 0.8 |
| CKD | 27.9 (1.0) | 28.3 (1.1) | –0.4 (1.1) | 0.7 | |
| LVESV (mL) | |||||
| No CKD | 216.4 (9.9) | 210.5 (10.8) | 5.9 (4.9) | 0.2 | 0.5 |
| CKD | 182.6 (9.3) | 183.2 (10.2) | –0.54 (7.0) | 0.9 | |
| LVEDV (mL) | |||||
| No CKD | 287.0 (11.2) | 279.2 (11.9) | 7.7 (5.7) | 0.2 | 0.4 |
| CKD | 250.4 (10.4) | 252.0 (11.6) | –1.6 (8.0) | 0.8 | |
| LVESD (cm) | |||||
| No CKD | 5.7 (0.1) | 5.7 (0.2) | 0.02 (0.09) | 0.9 | 0.07 |
| CKD | 5.6 (0.2) | 5.9 (0.2) | –0.3 (0.2) | 0.06 | |
| LVEDD (cm) | |||||
| No CKD | 7.0 (0.1) | 6.9 (0.1) | 0.08 (0.07) | 0.3 | 0.7 |
| CKD | 6.9 (0.2) | 6.9 (0.2) | 0.03 (0.13) | 0.8 | |
| LV mass (g) | |||||
| No CKD | 298.5 (10.5) | 288.9 (10.6) | 9.6 (6.5) | 0.1 | 0.9 |
| CKD | 255.5 (12.7) | 245.9 (15.9) | 9.6 (7.7) | 0.2 | |
| Mitral regurgitation (%) | |||||
| No CKD | 15.1 (1.6) | 14.5 (1.8) | 0.6 (1.2) | 0.6 | 0.03 |
| CKD | 18.4 (1.3) | 20.1 (1.7) | –1.7 (0.9) | 0.2 | |
| LV cavity shape–diastole | |||||
| No CKD | 0.54 (0.01) | 0.53 (0.01) | 0.02 (0.10) | 0.08 | 0.2 |
| CKD | 0.55 (0.02) | 0.55 (0.02) | –0.006 (0.01) | 0.6 | |
| IVMD (ms) | |||||
| No CKD | 34.4 (4.0) | 36.7 (4.1) | –2.3 (3.3) | 0.5 | 0.4 |
| CKD | 23.5 (5.2) | 19.8 (7.3) | 3.7 (6.4) | 0.6 | |
| MPI | |||||
| No CKD | 929 (14) | 915 (15) | 14 (14) | 0.3 | 0.07 |
| CKD | 950 (22) | 994 (34) | –44 (34) | 0.2 | |
CKD, chronic kidney disease; IVMD, interventricular mechanical delay; LV cavity shape–diastole, left ventricular cavity shape at end-diastole; LVEDD, left ventricular end-diastolic diameter; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic diameter; LVESV, left ventricular end-systolic volume; LV mass, left ventricular mass; MPI, myocardial performance index.
aValues represent the mean (standard error).