Table 5.
Linear hierarchical regression with cognition (MMSE and verbal fluency) as dependent variable, WMH volume as independent variable, and controlling for years of education
| Independent and dependent variable (controlling for education) | R2 | R2 change | F change (df1, df2) | Sig. F change | Beta (Educ. WMH) | Sig. (Educ. WMH) |
|---|---|---|---|---|---|---|
| MMSE vs. tot_WMH | 0.299 | 0.054 | 4.445 (1, 58) | 0.039 | 0.447 | 0.000 |
| −0.237 | 0.039 | |||||
| MMSE vs. frontal WMH | 0.294 | 0.049 | 4.030 (1, 58) | 0.049 | 0.434 | 0.000 |
| −0.230 | 0.049 | |||||
| Fluency vs. tot_WMH | 0.153 | 0.003 | 0.182 (1, 57) | 0.671 | 0.377 | 0.004 |
| −0.053 | 0.671 | |||||
| Fluency vs. frontal WMH | 0.158 | 0.008 | 0.535 (1, 57) | 0.467 | 0.363 | 0.006 |
| −0.092 | 0.467 | |||||
tot_WMH = Total WMH volume; Sig. = significant; Educ. = education.