Fig. 3. Omcg1 loss of function in intestinal epithelium leads to massive apoptosis of crypt cells.

(A) Histological analysis of control and VT2O^cKO mice intestine at different time points following TAM injection. Asterisks: abnormal mitotic cells; arrowheads: round acidophilic cell with apoptotic nuclear bodies, arrows: dilated lymph vessels showing oedematous mucosa. (B) Cleaved caspase-3 immunostaining 0, 48 and 60 hours after injection. (C) Mean (± SD) percentage of caspase-3 positive cells per crypt (n-s: non-significant; ***: p<0.001, Mann-Whitney-Wilcoxon test).