Fig. 4. Absence of proliferation arrest and double-strand breaks in Omcg1-deficient crypt cells.

(A) BrdU immunostaining of small intestine sections at 60h following TAM injection. (B) Mean (± SD) percentage of BrdU positive cells per crypt (n-s: non-significant; *: 0.01<p<0.05, Mann-Whitney-Wilcoxon test). (C) Anti-γH2AX immunostaining of control and VT2O^CKO mice 48h following TAM injection. Wild-type mice 1h post irradiation (10 Gy) were used as positive controls.