Fig. 1.

Results from mucosal-to-serosal flux of ⁵¹Cr-EDTA in jejunal tissue samples (a), and enteric bacterial translocation to jejunal mesenteric lymph nodes (b) using HCD4/HLA-DQ8 transgenic mice. We studied non-sensitized mice orally challenged with rice cereal (a: NS-rice, n = 9) or indomethacin (a: NS-Indo, n = 5) as well as animals sensitized and orally challenged with gliadin (a: Gliadin, n = 7) alone or in the presence of the paracellular permeability inhibitor AT1001 at low and high dose (a: Gliadin + AT1001, n = 8 each group). Values in black bars are mean ± SEM (A: *p < 0.05 versus NS-rice and Gliadin + AT1001 at low and high dose). Dot plots and mean values (horizontal lines) are shown in (b)