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. 2012 Nov 2;23(12):1977–1986. doi: 10.1681/ASN.2012040383

Figure 5.

Figure 5.

Podocyte VDR signaling inhibits proapoptotic pathways. (A and B) Western blots (A) and densitometric quantitation (B) showing Bcl2 and Bad levels in glomerular lysates isolated from different mice. *P<0.05 versus the rest. (C–E) Western blots (C and D) and quantitation (E) showing levels of p53, Bad, Bcl2, and VDR in podocyte lysates under different cultural conditions as indicated. *P<0.05; **P<0.01 versus the rest. (F and G) Time course changes (F) and quantitation (G) in the levels of phospho-AKT, AKT, phospho-ERK, ERK, phospho-p38, and p38 in podocytes cultured in LG and HG conditions at different times (15 minutes to 24 hours) after 1,25-dihydroxyvitamin D treatment. **P<0.01 versus the rest. (H and I) Western blots (H) and quantitation (I) showing phosphorylation of MAPKAPK2 and p38 under different conditions. *P<0.05. VD, 1,25-dihydroxyvitamin D; M, mannitol; SB, SB203580. All Western blots are representative of at least three independent experiments.