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. Author manuscript; available in PMC: 2012 Nov 27.
Published in final edited form as: J Biochem Mol Toxicol. 2010 Sep-Oct;24(5):330–334. doi: 10.1002/jbt.20342

Figure 4. Model for the activation of MT transcription by ROS.

Figure 4

ROS reacts with lipids to produce HNE. HNE then activates protein kinases which ultimately affect MT expression. Once produced, MT can then scavenge ROS; decreasing HNE and kinase activation ultimately reducing MT expression.