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. 2012 Nov 1;11(21):3983–3996. doi: 10.4161/cc.22215

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Copyright © 2012 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name cc-11-3983-g2.jpg — Figure 2. DNA2 and EXO1 are required for resection at ICL-induced damage. (A) shDNA2/EXO1 siRNA-treated cells exposed to cisplatin (15 μM, 24 h) show reduced phosphorylation of RPA2 S4/S8, S33 and Chk1 S345 compared with shSCR-treated cells . (B) shDNA2’/EXO1 siRNA-treated cells exposed to cisplatin (15 μM, 24 h) show reduced phosphorylation of RPA2 S4/S8, S33 and Chk1 S345 compared with shSCR-treated cells and ectopically expressed, RNAi-resistant DNA2 restored RPA and Chk1 phosphorylation in depleted U2OS cells (C). CDDP,cisplatin. Experiments were performed at least twice. See also Figure S2. See Experimental Procedures for details.