Figure 4. Molecular pathways of cystogenesis affected by CDK inhibitors R-roscovitine and S-CR8 in kidneys from Pkd1 cKO mice. Representative immunoblots show expression of markers in total kidney extracts from wild-type controls (WT) and Pkd1 cKO animals (cKO) treated with vehicle (V), R-roscovitine (R) or S-CR8 (S). Shown are effects of CDK inhibitors on cell cycle markers (A), apoptotic pathway (B) and transcriptional inhibition (C).