Table 1. Anti-cystic effect of CDK inhibitors R-roscovitine and S-CR8 in Pkd1 cKO mice .
| No | No of animals |
K/BW ratio (%) | Kidney cystic volume (%BW) |
BUN (mg dl–1) |
Liver cystic tissue (%) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |
Vehicle |
27 |
4.98 |
± |
0.26 |
1.63 |
± |
0.14 |
113 |
± |
11 |
4.62 |
± |
0.53 |
| 2 |
R-roscovitine |
14 |
3.29 |
± |
0.39* |
0.80 |
± |
0.16* |
61 |
± |
12* |
2.25 |
± |
0.25* |
| 3 | S-CR8 | 19 | 2.55 | ± | 0.19* | 0.34 | ± | 0.07* | 45 | ± | 4* | 1.48 | ± | 0.19* |
*
indicates p < 0.05 for reduction in drug-treated vs. vehicle-treated animals. Values expressed as mean ± SEM.