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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Mol Cancer Ther. 2012 Sep 18;11(11):2311–2320. doi: 10.1158/1535-7163.MCT-12-0009

Figure 2. Knockdown of PTK6 in HCT116 cells enhances apoptosis following γ-irradiation.

Figure 2

(A) Stable HCT116 p53+/+ and p53 −/− cells containing empty vector shRNA (V) or one of two different shRNAs (49 or 52) that target PTK6 were exposed to 20Gy of γ-irradiation and harvested at 0, 6 and/or 48 hours post-treatment. Immunoblotting was performed using antibodies against PTK6 and p53; (B) PTK6, p53 and p21; and (C) PTK6 and the cleaved forms of Caspase 3 and PARP. β-actin was examined as a loading control.