Table 1.
Selected characteristics of hepatitis C virus-viremic/HIV-positive women with normal aspartate aminotransferase to platelet ratio index at baseline (N = 302).
| Variable | N (%)a |
|---|---|
| Race/ethnicity | |
| African-American | 184 (61) |
| Hispanic | 63 (21) |
| Other | 4 (1) |
| Caucasian | 51 (17) |
| Age (years) | |
| < 30 | 17 (6) |
| 30–35 | 74 (25) |
| 36–45 | 175 (58) |
| > 45 | 36 (12) |
| Body mass index (kg/m2) | |
| Underweight (< 18.5) | 8 (3) |
| Normal (18.5–25.0) | 130 (45) |
| Overweight (> 25.0–30.0) | 85 (30) |
| Obese (> 30.0) | 63 (22) |
| Injection drug use | |
| Never | 42 (14) |
| Former | 188 (62) |
| Current | 72 (24) |
| Alcohol consumption | |
| Abstains | 131 (45) |
| Light (<3 drinks/week) | 63 (22) |
| Moderate (3–13 drinks/week) | 54 (18) |
| Heavy (> 13 drinks/week) | 45 (15) |
| Hepatotoxic medicationsb | |
| No | 166 (55) |
| Yes | 136 (45) |
| CD4 T-cell count (per ml) | |
| < 200 | 62 (21) |
| 200–500 | 139 (47) |
| > 500 | 97 (33) |
| HIV-RNA level (copies/ml) | |
| < 4000 | 99 (33) |
| 4001–20 000 | 59 (20) |
| 20 001–100 000 | 67 (22) |
| > 100 000 | 77 (25) |
| Clinical AIDS at baseline | |
| No AIDS | 186 (62) |
| AIDS | 114 (38) |
| IGFBP-3 (‘quartile’)c | |
| Q1 | 103 (34) |
| Q2 | 84 (28) |
| Q3 | 66 (22) |
| Q3 | 49 (16) |
| IGF-I (‘quartile’)c | |
| Q1 | 111 (37) |
| Q2 | 80 (26) |
| Q3 | 71 (24) |
| Q4 | 40 (13) |
Percentages (%) do not always add up to 100% as a result of rounding. The total number of subjects does not always equal 302 because of the unavailability of the indicated data.
Hepatotoxic drugs (per US treatment guidelines) [15] included: azithromycin, clarithromycin, delavirdine, efavirenz, fluconazole, isoniazid, itraconazole, ketoconazole, nevirapine, protease inhibitors, rifabutin, rifampin, voriconazole.
Serocutoffs for insulin-like growth factor (IGF) I and insulin-like growth factor binding protein (IGFBP) 3 were defined using the quartile values obtained in a random subsample of HIV-uninfected women enrolled in the WIHS. For IGF-I these serocutoffs were: 173, 219, and 275 ng/ml. For IGFBP-3 these serocutoffs were: 2497, 3094, and 3660 ng/ml.