Table 3.

Most significant and largest (effect size) SNP associations in candidate analysis regions by ethnic group, MESA

		CAU (n=2349)		CHN (n=664)		AFA (n=1366)		HIS (n=1171)
		Most significant	Largest β	Most significant	Largest β	Most significant	Largest β	Most significant	Largest β
	rs#	rs10830963	rs10830963	rs1597023	rs3781637	rs10830963	rs10830964	rs10830963	rs3781637
MTNR1B	β* (SE)	1.43 (.32)	1.43 (.32)	−1.61 (.59)	2.44(1.18)	1.64 (.73)	−1.73(1.08)	1.31(.55)	2.84 (1.43)
	p	8.3 E −6	8.3 E −6	.0067	.039	.024	.11	.02	.05
	MAF   (minor allele / major allele)	.27 (G/C)	.27 (G/C)	.33 (G/A)	.13 (T/C)	.08 (G/C)	.04 (G/C)	.20 (G/C)	.04 (T/C)
	Imputation score††	NA	NA	.99	.51	NA	NA	NA	.49
	rs#	rs3757840	rs1799884	rs2300587	rs741036	rs2908290	rs2268569	rs1799884	rs2268569
GCK	β* (SE)	1.07 (.30)	1.24 (.36)	1.98(.67)	2.19 (1.01)	−1.53(.43)	1.73 (.63)	1.54(.54)	−2.18 (1.07)
	p	.00035	.00055	.0029	.03	.00045	.0065	.0047	.043
	MAF (minor allele / major allele)	.47 (T/G)	.17 (T/C)	.23 (T/C)	.08 (G/A)	.48 (G/A)	.21 (T/G)	.21 (T/C)	.11 (T/G)
	Imputation score††	.87	NA	.96	NA	.99	.62	NA	.44
	rs#	rs560887	rs13430620	rs10497347	rs3821117	rs2232328	rs3821117	rs1402837	rs13431683
G6PC2	β* (SE)	−1.64(.31)	−2.63(1.06)	−1.18 (.59)	−2.31(1.88)	−0.76 (.41)	.85 (.46)	1.64 (.55)	−5.17 (1.88)
	p	1.8 E −7	.013	.045	.22	.06	.06	.0029	.0059
	MAF (minor allele / major allele)	.28 (T/C)	.04 (C/A)	.30 (T/C)	.023 (T/C)	.49 (G/C)	.27 (T/C)	.22 (T/C)	.013 (G/C)
	Imputation score††	NA	.40	NA	NA	NA	NA	.93	NA

β, SE, and p-value are for regression of fasting glucose on SNP, adjusted for age, gender, study center and ethnic-specific PCs

^*Difference in fasting glucose (mg/dl) per 1 increase in the minor allele(additive model)

^††oevar_imp from MACH [Li, et al. 2009], SNPs that were genotyped have score listed as NA