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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Immunol. 2012 Oct 29;189(11):5434–5441. doi: 10.4049/jimmunol.1201621

Figure 4.

Figure 4

Effect of CD59a deficiency on renal disease of MRL/lpr mice. Male Cd59a−/−MRL/lpr (CD59a−/−) mice developed significantly increased proteinuria (A) and glomerular/tubular IgG deposition (C) compared with male Cd59a+/+ MRL/lpr (CD59a+/+) littermates. ** p<0.05, Mann-Whitney test. There was no significant difference in glomerular nephritis scores (B) and glomerular/tubular C3 staining (D) between Cd59a−/−- and Cd59a+/+-MRL/lpr mice. Scores for IgG and C3 deposition represent composite scores of glomerular/tubular staining (maximal score 6).