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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: J Immunol. 2012 Oct 29;189(11):5434–5441. doi: 10.4049/jimmunol.1201621

Figure 6.

Figure 6

Effect of C3 gene deletion on lymphoproliferation and skin disease development in Cd59a−/− MRL/lpr mice. C3−/−-Cd59a−/−-MRL/lpr mice and Cd59a−/−-MRL/lpr mice were produced as littermates and studied for 5 months. No difference was seen in splenomegaly (A) and lymphadenopathy (B) between the two genotypes. There was also no difference between C3−/−-and C3+/+-Cd59a−/−-MRL/lpr mice in the percentage of abnormal T cells (C) or single-positive (CD4+ or CD8+) T cells (D) in their lymph nodes. C3 gene deletion did not reduce the incidence of open skin lesions (E) but reduced open skin lesion size (F) in Cd59a−/−-MRL/lpr mice. Numbers of mice for panel C are indicated on the graph. In panel E, average lesion size (mean ± SED) was only for mice with open lesions (numbers indicated above the columns) among the same mice studied in C.