Table 1.
Numbers of genes (with known or predicted functions) that exhibited significant up- or down-regulation after inactivation of ccpA
|
Function category |
No. of genes affected by ccpA inactivation |
|||||||
|---|---|---|---|---|---|---|---|---|
| |
M (Middle exponential phase) |
L (Late exponential phase) |
T (Transition phase) |
S (Stationary phase) |
||||
| Up-regulation | Down-regulation | Up-regulation | Down-regulation | Up-regulation | Down-regulation | Up-regulation | Down-regulation | |
| G. Carbohydrate transport and metabolism |
96 |
9 |
96 |
10 |
84 |
10 |
103 |
9 |
| E. Amino acid transport and metabolism |
38 |
28 |
9 |
38 |
31 |
52 |
42 |
18 |
| H. Coenzyme transport and metabolism |
21 |
12 |
10 |
11 |
16 |
9 |
22 |
22 |
| R. General function prediction only |
20 |
19 |
20 |
24 |
24 |
23 |
24 |
36 |
| K. Transcription |
19 |
13 |
20 |
13 |
22 |
13 |
25 |
22 |
| F. Nucleotide transport and metabolism |
14 |
4 |
14 |
1 |
13 |
3 |
11 |
7 |
| T. Signal transduction mechanisms |
11 |
15 |
12 |
7 |
11 |
19 |
19 |
10 |
| C. Energy production and conversion |
10 |
22 |
5 |
15 |
9 |
11 |
16 |
12 |
| I. Lipid transport and metabolism |
9 |
3 |
9 |
3 |
9 |
2 |
11 |
14 |
| O. Posttranslational modification, protein turnover, chaperones |
9 |
10 |
2 |
17 |
5 |
16 |
7 |
8 |
| N. Cell mobility |
8 |
12 |
11 |
4 |
7 |
12 |
14 |
3 |
| M. Cell wall/membrane biogenesis |
8 |
16 |
10 |
10 |
9 |
20 |
13 |
35 |
| P. Inorganic ion transport and metabolism |
8 |
22 |
5 |
25 |
11 |
17 |
25 |
18 |
| J. Translation |
6 |
5 |
10 |
3 |
5 |
3 |
6 |
38 |
| L. Replication, recombination and repair |
5 |
2 |
9 |
1 |
3 |
0 |
4 |
12 |
| Q. Secondary metabolites biosynthesis, transport and catabolism |
4 |
1 |
3 |
1 |
3 |
1 |
3 |
6 |
| V. Defense mechanisms |
2 |
3 |
2 |
1 |
4 |
2 |
5 |
7 |
| D. Cell cycle control, mitosis and meiosis |
1 |
1 |
2 |
1 |
1 |
1 |
2 |
4 |
| U. Intracellular trafficking and secretion |
1 |
0 |
1 |
0 |
2 |
0 |
4 |
4 |
| S. Function unknown |
11 |
22 |
12 |
21 |
13 |
20 |
18 |
37 |
| Not in COGs |
93 |
57 |
115 |
46 |
75 |
50 |
124 |
149 |
| Total | 370 | 266 | 352 | 244 | 330 | 278 | 465 | 471 |