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Schematic representation of glycolysis and the Krebs cycle highlighting the theoretical isotopic distribution (•) within specific metabolites derived from [1-13C]Glc. Numbers represent routes of synthesis for the specific metabolites discussed in the text. Enzymes: (a) PK; (b) PEPC; (c) Ala aminotransferase; (d) ME; (e) Glu dehydrogenase, Glu synthetase/Glu synthase, and aminotransferases; and (f) Asp aminotransferase. PPP, Pentose phosphate pathway.
