Table 3.
Differences between survivors without significant BPD and deceased or surviving infants with significant BPD
|
SWsBPD |
Deceased/Significant BPD |
p-value* | |
|---|---|---|---|
| (n = 299) | (n = 116) | ||
| Year of birth |
|
|
0.032 |
| - 1997–2000 |
38 (58.5%) |
27 (41.5%) |
|
| - 2001–2005 |
132 (74.2%) |
46 (25.8%) |
|
| - 2006–2009 |
129 (75.0%) |
43 (25.0%) |
|
| Gestational age (w) |
27.6 (26.1-29.4) |
25.4 (24.4-27.0) |
<0.001 |
| Birth weight (g) |
850 (750–935) |
680 (589–780) |
<0.001 |
| IUGR |
112 (38.5%) |
37 (34.9%) |
0.515 |
| Multiple gestation |
102 (34.1%) |
48 (41.4%) |
0.167 |
| Male gender |
135 (45.2%) |
63 (54.3%) |
0.094 |
| Chorioamnionitis |
48 (16.1%) |
33 (28.4%) |
0.004 |
| Antibiotics (mother) |
167 (59.6%) |
78 (69.6%) |
0.065 |
| Prenatal steroids |
277 (95.2%) |
97 (84.3%) |
<0.001 |
| Cesarean section |
213 (72.0%) |
53 (45.7%) |
<0.001 |
| Apgar at 1 minute ≤3 |
29 (9.7%) |
37 (32.5%) |
<0.001 |
| Apgar at 5 minutes ≤6 |
29 (9.7%) |
32 (28.3%) |
<0.001 |
| Umbilical artery pH |
7.26 (7.17-7.31) |
7.29 (7.19-7.32) |
0.165 |
| Resuscitation |
|
|
<0.001 |
| - Not performed |
67 (22.4%) |
6 (5.2%) |
|
| - Mask/IPPV + PEEP |
121 (40.5%) |
20 (17.2%) |
|
| - ET intubation |
102 (34.1%) |
79 (68.1%) |
|
| - ET Intubation + |
|
|
|
| chest compression + |
|
|
|
| epinephrine |
9 (3.0%) |
11 (9.5%) |
|
| CRIB |
4 (1–6) |
9 (7–13) |
<0.001 |
| RDS |
146 (48.8%) |
92 (79.3%) |
<0.001 |
| Mechanical ventilation |
184 (61.5%) |
116 (100%) |
<0.001 |
| Sepsis |
124 (41.5%) |
54 (46.6%) |
0.349 |
| NEC |
17 (5.7%) |
13 (11.2%) |
0.052 |
| IVH |
52 (17.4%) |
45 (38.8%) |
<0.001 |
| - Grades III/IV |
11 (3.7%) |
34 (29.3%) |
<0.001 |
| PVLM |
6 (3.1%) |
4 (4.5%) |
0.536 |
| PDA |
105 (35.1%) |
43 (37.1%) |
0.710 |
| - Surgical closure |
25 (8.4%) |
6 (5.2%) |
0.268 |
| Severe arterial |
|
|
|
| hypotension | 10 (3.4%) | 30 (26.1%) | <0.001 |
CRIB: clinical risk index for babies; IUGR: intrauterine growth restriction; ET: endotracheal; RDS: respiratory distress syndrome; NEC: necrotizing enterocolitis; IVH: peri-intraventricular hemorrhage; PEEP: positive end expiratory pressure; PVLM: periventricular leukomalacia; PDA: patent ductus arteriosus; SWsBPD: survival without significant BPD.
Median (IQR: 25th-75th percentile), number (%).
* Mann–Whitney U or chi-square test.