Table 6. Cox proportional hazards regression analysis (forward stepwise: likelihood ratio).

Variables	Wald statistic	Hazard ratio (95% CI )	P
Age	10.958	1.052(1.020–1.084)	0.001
Cervical lymph node metastasis	17.677	3.131(1.839–5.331)	<0.001
Distant metastasis	13.728	7.022 (2.504–19.687)	<0.001
Histologic differentiation	9.764	1.847(1.257–2.713)	0.002
Smoking	7.709	2.671(1.335–5.334)	0.005
Fascin-1	5.702	3.607(1.259–10.340)	0.017
Ezrin	7.614	3.584(1.447–8.873)	0.006

95% CI, 95% confidence interval.