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. 2012 Nov 27;7(11):e50805. doi: 10.1371/journal.pone.0050805

Figure 1. Changes in the withdrawal latency with a hot-plate test in resiniferatoxin (RTX)-induced neuropathy.

Figure 1

Thermal responses were evaluated by the hot-plate test at 52°C in the vehicle (open squares) and RTX groups (filled squares). Withdrawal latencies remained the same in the vehicle group. Thermal hypoalgesia was induced on RTX-treatment day 7 (RTXd7, p<0.001) and persisted to RTXd49 (p<0.01), and the withdrawal latency had become normalized by RTXd56 (p>0.05), persisted to RTXd84 (p>0.05). Comparisons of hot-plate latencies (n = 5 at each time point) were analyses by two-way repeated measures ANOVA followed Bonferroni’s post-hoc test. *p<0.05, **p<0.01, ***p<0.001.