Skip to main content
. 2012 Nov 27;7(11):e50668. doi: 10.1371/journal.pone.0050668

Figure 1. HMGB1 stimulated TNF-α and IL-1β production in KCs from sham and burn rats.

Figure 1

KCs responded to an in vitro HMGB1 challenge with a significant and dose-dependent increase in TNF-α and IL-1β secretion. HMGB1 induced significantly greater amounts of TNF-α and IL-1β secretion in KCs from burn rats compared to those from sham animals. (A) TNF-α release by KCs from sham and burn rats. (B) IL-1β release by KCs from sham and burn rats. Results were given as mean±SEM (n = 8). & = p<0.05, && = p<0.01 vs. related sham group.