Table 4.
Individual SNPs associated with waist circumference or insulin resistance in GWAS in relation to MetS and MetS-score
| MetS | MetS-score | |
|---|---|---|
|
n |
1886 |
1886 |
|
WC |
|
|
| FTO rs1421085 |
1.02(0.93; 1.12) |
0.05(−0.03; 0.14) |
| MC4Rrs17782313 1 |
1.16(1.02; 1.32) |
0.10(−0.05; 0.24) |
|
IR |
|
|
| PPARG rs1801282 |
1.04(0.91; 1.19) |
0.10(−0.02; 023) |
| IRS1 rs2943634 |
0.88(0.79; 0.97) |
−0.14(−0.23;-0.06) |
| GCKR rs780094 |
0.99(0.89; 1.09) |
0.05(−0.04; 0.13) |
| IGF1 rs35767 |
1.03(0.91; 1.16) |
0.03(−0.08; 0.14) |
| GCK rs1799884 | 1.07(0.95; 1.20) | 0.08(−0.03; 0.22) |
Data are presented as PR per minor allele for MetS and as minor allele change for MetS Score; Mets Metabolic syndrome, WC waist circumference, IR insulin resistance.
All analyses are adjusted for age, sex and cohort.
1Data available in 853 women.