Table 3.
Comparison of the haplotype frequencies in the GSTA gene cluster of the populations from Tver, Murom, and Kursk with those from the HapMap Project (CEU, CHB, JPT, and YRI) *
| MUROM | KURSK | СЕU | CHB | JPT | YRI | Number of haploblock | The level of significance | |
|---|---|---|---|---|---|---|---|---|
| TVER |
0,6746 |
0,8353 |
0,8534 |
<0,0001 |
<0,0001 |
0,0269 |
I |
0,004 |
| |
0,9599 |
0,4282 |
0,6984 |
<0,0001 |
<0,0001 |
<0,0001 |
II |
0,0025 |
| |
0,9030 |
0,3306 |
0,0403 |
<0,0001 |
<0,0001 |
<0,0001 |
III |
0,0025 |
| |
0,8238 |
0,2076 |
0,0326 |
<0,0001 |
<0,0001 |
0,0065 |
IV |
0,0019 |
| |
0,0484 |
0,3957 |
0,2428 |
― |
― |
0,6452 |
V |
0,0025 |
| |
0,4538 |
0,9276 |
0,4634 |
― |
― |
― |
VI |
0,0025 |
| MUROM |
|
0,4641 |
0,4574 |
<0,0001 |
<0,0001 |
<0,0001 |
I |
0,004 |
| |
|
0,5661 |
0,5307 |
<0.0001 |
<0.0001 |
<0,0001 |
II |
0,0025 |
| |
|
0,1764 |
0,1188 |
<0.0001 |
<0.0001 |
<0,0001 |
III |
0,0025 |
| |
|
0,1599 |
0,0408 |
<0,0001 |
<0,0001 |
0,0006 |
IV |
0,0019 |
| |
|
0,5052 |
0,5524 |
― |
― |
0,0031 |
V |
0,0025 |
| |
|
0,2664 |
0,8195 |
― |
― |
― |
VI |
0,0025 |
| KURSK |
|
|
0,9266 |
<0,0001 |
<0,0001 |
0,0097 |
I |
0,004 |
| |
|
|
0,1321 |
<0.0001 |
<0.0001 |
<0,0001 |
II |
0,0025 |
| |
|
|
0,0013 |
<0.0001 |
<0.0001 |
<0.0001 |
III |
0,0025 |
| |
|
|
0,2053 |
<0,0001 |
<0,0001 |
0,0006 |
IV |
0,0019 |
| |
|
|
0,9682 |
― |
― |
0,1181 |
V |
0,0025 |
| 0,2694 | ― | ― | ― | VI | 0,0025 |
* Pairwise P-values are presented. The last column contains Bonferroni adjusted P-values calculated for each block. The calculations was performed using the formula P = 0.05/ ([n × a] – 1), where “n” is the number of haplotypes and “a” is the number of populations [16]. The absence of some haploblocks in the CHB, JPT, and YRI populations did not allow us to compare these populations; the respective columns are marked with dashes on the corresponding lines.