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. 2012 Nov 27;7(11):e49810. doi: 10.1371/journal.pone.0049810

Figure 2. Phylogram of Msi family sequences.

Figure 2

Vertebrates contain two Msi paralogues, Msi2 (red box) and Msi1 (yellow box). A single orthologue found in the hemichordate (Msih_Sk) is closely aligned with the vertebrate sequences. The Rbp6 clade (blue box) of Msi proteins is insect-specific but also more closely aligned with the vertebrate proteins than the single orthologues found in nematodes. The Msi clade (orange box) is a more highly derived insect-specific group of proteins. Single representatives of the Msi family can be found in Trichoplax and Schistosoma. The RRM-containing protein, Hrb27c, was used as an outgroup. Mm: Mus musculus (mouse), Hs: Homo sapiens (human), Gg: Gallus gallus (chicken), Tg: Taeniopygia guttata (zebra finch), Dr: Danio rerio (zebra fish), Sk: Saccoglossus kowalevskii (acorn worm/hemichordate), Nv: Nasonia vitripennis (jewel wasp), Tc: Tribolium castaneum (red flour beetle), Dm: Drosophila melanogaster (fruit fly), Da: Drosophila ananassae (fruit fly), Dg: Drosophila grimshawi (fruit fly), Dmo: Drosophila mojavensis (fruit fly), Ce: Caenorhabditis elegans (nematode), Cb: Caenorhabditis briggsiae (nematode), Ta: Trichoplax adhaerens (placozoan), Sj: Schistosoma japonicum (blood fluke).