Fig. 4.

Aβ accumulation in the brain of SO and OBX mice. Bars indicate the level of Aβ peptides (mean ± SEM) in the indicated groups of experimental mice (n = 6–11 per group). a Aβ was determined by DOT analysis or b ELISA (see “Materials and methods”). The bottom panel shows the level of Aβ peptides in OBX group as values (mean ± SEM) relative to the content in SO group. The absolute value of Aβ in SO animals was 0.45 рМ/g in the brain tissue (cortex + hippocampus). Differences between the levels of Aβ in the groups were determined by using the two-tailed Student's t test