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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Acta Biomater. 2012 Aug 16;9(1):4635–4644. doi: 10.1016/j.actbio.2012.08.007

Figure 7.

Figure 7

Angiogenic outgrowth response to matrix stiffness. Multi-cellular spheroids were embedded within collagen polymerized from solutions treated with 0, 50, or 100 mM ribose. (a) Spheroids were imaged using brightfield microscopy at 0, 1, and 2 days after embedding. (b) The total length of extensions and (c) the average number of extensions per spheroid were measured at day 1. (d) The projected spheroid area, including the extensions, was measured over the course of 5 days. Data presented as mean + SEM, * indicates p<0.05, Scale is 200 μm