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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Hepatology. 2012 Dec;56(6):2094–2105. doi: 10.1002/hep.25951

Figure 6. Effect of supernatants from HCV-stimulated IHL on fibrogenic activation of HSC.

Figure 6

Supernatants from IHL stimulated with media (control), HCV-Core pool-1, pool-2 and pool-3 peptides (1:20 dilutions of conditioned media) were incubated with cultures of human HSC (LX-2 cell line) for 24 h. The HSC fibrogenic RNA response was assessed by qRT-PCR for COL1A1 and MMP-1 normalized to B2M, shown as relative fold change to media control. In comparison to media, HCV-stimulated supernatants from slow progressors (SP), but not rapid progressors (RP) induced expression of putatively fibrolytic MMP-1, but not of pro-fibrogenic COL1A1. Stars indicate significant difference (p<0.05).