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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Hepatology. 2012 Dec;56(6):2094–2105. doi: 10.1002/hep.25951

Figure 7. Effect of treating IHL supernatants or IHL cultures with anti-TGFβ on HSC.

Figure 7

Response of LX-2 human hepatic stellate cells to T cell supernatnats (SN) from 3 slow progressors in whom blocking TGFβ in IHL Elispot assay increased HCV-specific IFNγ response. Either SN were harvested from IHL culture ±HCV stimulation then treated with anti-TGFβ mAb prior to co-culture with LX-2 (SP-5) or IHL ±HCV were cultured with blocking Abs, then SN were harvested for co-culture with LX-2 (SP-6 and SP-7). Treatment with anti-TGFβ Ab (in comparison with Isotype control) abrogated induction of MMP-1 expression by HSC and also up-regulated COL1A1 (SP-7). Stars indicate significant difference (p<0.05).