Table 1. Demographics of studied subjects.

Liver histology scored by Metavir system or modified Ishak converted to Metavir scores. HAI: stage+grade. Progression rate for rapid progressors >0.1 Metavir/yr. ALT: alanine-aminotransferase.

	Rapid progressors	Slow progressors
Characteristic	(n = 6)	(n = 13)	P
Age: median (range), yr	57 (38 – 59)	57 (38 – 66)	0.67
Race	5 C; 1 Asian	10 C; 1 AA; 2 Asian
Male / female sex	5 / 1	9 / 4
HCV RNA, median (range), copies × 103 IU/mL	2,025 (594 – 17,800)	1,210 (31.5 – 14,600)	0.80
HCV genotype (no.)	1 (6)	1 (12), 3 (1)
ALT: median (range)	81 (34 – 101)	59 (34 – 417)	0.83
Liver Inflammation Grade: median (range)	1 (1 – 3)	1 (1 – 2)	0.47
Liver Fibrosis Stage: median (range)	2 (2 – 4)	1 (0 – 2)	0.006
Histological activity index (HAI): median (range)	3 (3 – 5)	2 (1 – 4)	0.009
Fibrosis progression rate: median (range), Metavir/yr	0.2 (0.1 – 0.67)	0.0 (−0.167 – 0.074)	0.0005
Time between 2 biopsies: median (range), yr	4.9 (3.46 – 5.21)	4.26 (3.85 – 6.76)	0.44