Table 2.
Baseline characteristics of study cohort by thyroid status. Values are numbers (percentages) unless stated otherwise
| Characteristic | Thyroid status | Total population (n=586 460) | ||||
|---|---|---|---|---|---|---|
| Overt hypothyroidism (n=1670) | Subclinical hypothyroidism (n=12 087) | Euthyroidism (n=562 461) | Subclinical hyperthyroidism (n=6276) | Overt hyperthyroidism (n=3966) | ||
| Mean (SD) age (years): | 53.7 (18.1) | 54.5 (18.5) | 48.6 (18.2) | 60.6 (19.4) | 51.8 (19.4) | 48.9 (18.3) |
| Women | 53.2 (18.4) | 54.7 (18.6) | 47.7 (19.0) | 60.3 (20.1) | 51.6 (19.8) | 48.1 (19.1) |
| Men | 55.6 (16.6) | 53.5 (18.1) | 50.0 (16.8) | 61.5 (16.8) | 52.8 (17.4) | 50.2 (16.9) |
| Sex: | ||||||
| Women | 1355 (81) | 9675 (80) | 336 520 (60) | 4784 (76) | 3171 (80) | 355 505 (61) |
| Men | 315 (19) | 2412 (20) | 225 941 (40) | 1492 (24) | 795 (20) | 230 955 (39) |
| Mean (SD) thyroid function: | ||||||
| TSH (mIU/L) | 63.77 (44.64) | 9.24 (7.24) | 1.56 (0.84) | 0.086 (0.061) | 0.038 (0.043) | 1.871 (4.428) |
| FT4 (pmol/L) | 6.28 (1.93) | 13.11 (2.18) | 15.05 (2.30) | 16.89 (2.62) | 42.61 (22.28) | 15.94 (8.27) |
| Comorbidity: | ||||||
| Peripheral vascular disease | 3 (0) | 19 (0) | 676 (0) | 17 (0) | 10 (0) | 725 (0) |
| Cerebral vascular disease | 6 (0) | 78 (1) | 3024 (1) | 57 (1) | 25 (1) | 3190 (1) |
| Ischaemic heart disease | 9 (1) | 59 (0) | 2652 (0) | 61 (1) | 19 (0) | 2800 (0) |
| Malignancy | 22 (1) | 72 (1) | 2552 (0) | 61 (1) | 26 (1) | 2733 (0) |
| COPD | 8 (0) | 48 (0) | 1930 (0) | 61 (1) | 26 (1) | 2073 (0) |
| Diabetes | 6 (0) | 39 (0) | 2381 (0) | 47 (1) | 19 (0) | 2492 (0) |
| Rheumatic disease | 1 (0) | 9 (0) | 363 (0) | 13 (0) | 4 (0) | 390 (0) |
| Chronic renal failure | 2 (0) | 7 (0) | 224 (0) | 6 (0) | 1 (0) | 240 (0) |
| Gastric ulcer | 3 (0) | 22 (0) | 1187 (0) | 25 (0) | 16 (0) | 1253 (0) |
| Congestive heart failure | 6 (0) | 35 (0) | 997 (0) | 32 (1) | 11 (0) | 1081 (0) |
| Charlson comorbidity index: | ||||||
| 0 | 1629 (97) | 11 929 (98) | 556 268 (98) | 6104 (96) | 3930 (97) | 579 860 (98) |
| 1 | 24 (1) | 179 (1) | 7418 (1) | 157 (2) | 73 (2) | 7842 (1) |
| 2 | 23 (1) | 89 (1) | 3037 (1) | 78 (1) | 28 (1) | 3255 (1) |
| ≥3 | 6 (0) | 38 (0) | 1669 (0) | 34 (0) | 19 (0) | 1766 (0) |
| Yearly family income, by quintiles: | ||||||
| 0 | 234 (14) | 2096 (18) | 103 987 (19) | 1320 (21) | 732 (19) | 108 369 (19) |
| 1 | 384 (23) | 2741 (23) | 107 427 (19) | 1703 (28) | 930 (24) | 113 185 (20) |
| 2 | 357 (22) | 2467 (21) | 111 809 (20) | 1267 (21) | 799 (21) | 116 669 (20) |
| 3 | 352 (21) | 2336 (20) | 114 707 (21) | 1027 (17) | 765 (20) | 119 187 (21) |
| 4 | 321 (19) | 2230 (19) | 115 735 (21) | 833 (14) | 662 (17) | 119 781 (21) |
TSH=thyroid stimulating hormone, COPD=chronic obstructive pulmonary disease.